pentobarbital will lower the extent or impact of methadone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.pentobarbital will lessen the extent or result of norgestrel by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Closely. Reasonable CYP3A4 inducers may perhaps reduce